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Losses similar between groups at 6 months: NRT 53, placebo 58. Quote: "Both study staff and patients were blinded to patch treatment"Ħ3% of NRT participants and 44% of placebo participants correctly guessed their assignment Study funded by American Cancer Society Career Development Award, Marion Merrell Dow Inc, and Emory Medical Care FoundationĪ "computer‐generated random numbers table with a block size set at 20" Prolonged abstinence at 6 months (self‐report of no smoking since end of treatment) Level of support: high (1 h initial visit and brief follow‐up visits) Nicotine patch (21 mg with weaning, 10 weeks) Recruitment: hospital in‐ and outpatientsġ. If smoking from 0 to 3 cigarettes/week, and CO 0 to 11 ppm, counted as abstinent 75% of NRT group and 76% of placebo group correctly guessed their assignmentĭropouts similar between groups (NRT 20, placebo 21) 36/41 dropouts continued to smoke, but all 41 counted as treatment failures in ITT analysis

Method not stated described as "randomised, between‐subjects, double‐blind, and placebo‐controlled"īlinding (performance bias and detection bias) Random sequence generation (selection bias) Methods in Lancet paper, final follow up in Muller 1990. Sustained abstinence at 12 months (0 to 3 cigarettes/week) Level of support: low (number of visits unclear) Nicotine patch, 24 h, 12 weeks with weaning 21 mg smokers of > 20 cpd, 14 mg for < 20 cpd 40% female, average age 41, average cpd 27ġ.